Palmer turned professional and became a member of the LPGA Tour in 1964. She won 19 events on the Tour, and also several other professional events, including some as a senior. Her two wins in major championships came at the 1972 Titleholders Championship and the 1975 U.S. Women's Open. She topped the money list for 1975 and was awarded the LPGA Player of the Year title. Her ten top-10 finishes on the money list came in ten straight years from 1968 to 1977. She played her last event on the Tour in 1997.