SCF

• Southern Cathedrals Festival
• Sectional center facility (United States Postal Service)
• Service Control Function - an application of service logic to control functional entities in providing Intelligent Network services.
• Self-consistent field, one of the principal calculation approaches comprising Hartree–Fock method in quantum chemistry
• Shell Command File (.scf) - command files for Windows-Shell
• South Central Farm
• Standard cubic foot
• State College of Florida
• Stress Concentration Factor
• Supercritical fluid
• Supply Chain Finance
• Survey of Consumer Finances
• Svenska Cykelförbundet
• Stanley Cup Finals
• Shared Class Facility (SCF), at Crystal Space
• Spy Case Files
• Society of Crime Fighters (SCF) -a group of organized crime fighters led by Kyle Ross, Zoe Albright, Matthew Scott, and Virginia Ross.
• Simple continued fraction, a form of continued fraction

Associations

• Save the Children Fund
• Sahara Conservation Fund
• Scientific Committee on Food
• Singapore Chess Federation
• Singapore Canoe Federation

In biology

• SCF-complex (Skp1/Cul1/F-box complex), a ubiquitin ligase
• Stem cell factor a cytokine.