Selective serotonin reuptake enhancer

Selective Serotonin Reuptake Enhancer

Selective serotonin reuptake enhancer

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Description:
A selective serotonin reuptake enhancer (SSRE) is a type of drug which enhances the plasmalemmal reuptake of the neurotransmitter serotonin, leading to a decrease in its synaptic concentrations and therefore a decrease in serotonergic neurotransmission.

The only known drug of this class is tianeptine (Stablon, Coaxil, Tatinol), which is structurally related to the tricyclic antidepressants yet has an entirely distinct mechanism of action. The precise mechanism of action of tianeptine remains unclear despite several decades of research and clinical use, and while it has been speculated that tianeptine might act as an allosteric modulator of the serotonin transporter at a separate site to that used by SSRIs, newer research suggests that its direct action is actually alteration of AMPA glutamate receptor activity, which then leads to enhanced serotonin reuptake via a downstream mechanism which has yet to be fully characterised, but seems to involve altered neuroplasticity and release of BDNF.

SSREs are used as......
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