The school serves sections of Doraville and Chamblee as well as several unincorporated areas.
Brittany Cunningham currently serves as Principal of Sequoyah Middle School.
Originally a high school, Seqouyah Middle School was formed in 1964. It was built on grounds that were meeting places for Sequoyah Tribes. In 1989 it became a junior high school, and then again in 1996 it became a middle school.