Serotonin N-acetyl transferase

Serotonin N-Acetyl Transferase

Serotonin N-acetyl transferase

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Serotonin N-acetyl transferase also known as arylalkylamine N-acetyltransferase or AANAT is a protein that, in humans, is encoded by the AANAT gene.


The protein encoded by this gene is an enzyme involved in the conversion of serotonin to melatonin in pinealocytes. It is an acetyl-CoA-dependent enzyme of the GCN5-related family of N-acetyltransferases (GNATs).

Arylalkylamine N-acetyltransferase is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.


This family shares four conserved sequence motifs designated A-D. Motif B serves as the location of the serotonin binding slot. The structure of Serotonin N-acetyl transferase was determined by X-ray diffraction(XRD). A resolution of 1.80 angstroms was obtained. The structural weight is 24121.55 daltons. It is a polypeptide...
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