A serotonin receptor agonist
is a compound that activates serotonin receptors
, mimicking the effect of the neurotransmitter serotonin
. There are various serotonin receptors and ligands.
such as buspirone
, and tandospirone
are 5-HT<sub>1A</sub> agonists marketed primarily as anxiolytics
, but also recently as antidepressants
such as sumatriptan
, and naratriptan
, are 5-HT<sub>1B</sub> receptor agonists that are used to abort migraine
and cluster headache
In addition to being 5-HT<sub>1B</sub> agonists, triptans
are also agonists at the 5-HT<sub>1D</sub> receptor, which contributes to their antimigraine effect.
was a selective 5-HT<sub>1F</sub> agonist that was being developed by Eli Lilly and Company
for the treatment of migraine and cluster headaches. Development was halted however due to toxicity detected in animal test subjects. Lasmiditan
has successfully completed Phase II clinical trials in early 2010.
such as LSD
, and 2C-B
act as 5-HT<sub>2A</sub> agonists. Their action at this receptor is responsible for their hallucinogenic effects.
It is now known that many of these drugs act as agonists at... Read More