Serotonin receptor agonist

Serotonin Receptor Agonist

Serotonin receptor agonist

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A serotonin receptor agonist is a compound that activates serotonin receptors, mimicking the effect of the neurotransmitter serotonin. There are various serotonin receptors and ligands.

5-HT<sub>1A</sub> receptor

Azapirones such as buspirone, gepirone, and tandospirone are 5-HT<sub>1A</sub> agonists marketed primarily as anxiolytics, but also recently as antidepressants.

5-HT<sub>1B</sub> receptor

Triptans such as sumatriptan, rizatriptan, and naratriptan, are 5-HT<sub>1B</sub> receptor agonists that are used to abort migraine and cluster headache attacks.

5-HT<sub>1D</sub> receptor

In addition to being 5-HT<sub>1B</sub> agonists, triptans are also agonists at the 5-HT<sub>1D</sub> receptor, which contributes to their antimigraine effect.

5-HT<sub>1F</sub> receptor

LY-334,370 was a selective 5-HT<sub>1F</sub> agonist that was being developed by Eli Lilly and Company for the treatment of migraine and cluster headaches. Development was halted however due to toxicity detected in animal test subjects. Lasmiditan has successfully completed Phase II clinical trials in early 2010.

5-HT<sub>2A</sub> receptor

Psychedelic drugs such as LSD, mescaline, psilocin, DMT, and 2C-B act as 5-HT<sub>2A</sub> agonists. Their action at this receptor is responsible for their hallucinogenic effects.

It is now known that many of these drugs act as agonists at...
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