Sodium–hydrogen antiporter 3

Sodium–Hydrogen Antiporter 3

Sodium–hydrogen antiporter 3

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Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

SLC9A3 is a sodium–hydrogen antiporter. It is found in the nephron of the kidney and in the apical membrane of enterocytes of the intestine. It is primarily responsible for maintaining the balance of sodium.


Protein kinase C stimulates NHE3, while protein kinase A inhibits it.

There is a specific protein functioning as an NHE3 regulator, sodium–hydrogen antiporter 3 regulator 1.


Sodium-hydrogen antiporter 3 has been shown to interact with CHP.


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