Sodium-chloride symporter

Sodium-Chloride Symporter

Sodium-chloride symporter

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Description:
The sodium-chloride symporter (also known as <u>N</u>a<sup>+</sup>-<u>C</u>l<sup>-</sup> cotransporter, abbreviated as NCC or NCCT, or as the <u>t</u>hiazide-<u>s</u>ensitive Na<sup>+</sup>-Cl<sup>-</sup> <u>c</u>otransporter or TSC for short) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron.It is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the gene SLC12A3 (solute carrier family 12 member 3) located in 16q13.

Molecular biology

The sodium-chloride symporter or NCC is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporter, along with the potassium-chloride cotransporters (K<sup>+</sup>-Cl<sup>-</sup> cotransporters or KCCs), the sodium-potassium-chloride cotransporters (Na<sup>+</sup>-K<sup>+</sup>-Cl<sup>-</sup> cotransporters or NKCCs) and orphan member CIP (cotransporter interacting protein) and CCC9. The sodium-chloride symporter’s protein sequence has a high degree of identity between different mammalian species (over 90% between human, rat and mouse).

The ‘‘SLC12A3’’ gene encodes for a...
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