The line was originally built by the Atlantic and St. Lawrence Railroad in the U.S. and the St. Lawrence and Atlantic Railway in Canada, meeting at Island Pond, Vermont south of the International Boundary. Major communities served include Portland and Lewiston in Maine; Berlin, New Hampshire; Island Pond, Vermont; and Sherbrooke and Montreal in Quebec.
Milepost 1.5: Back Cove Trestle abandoned following fire damage in 1984
Milepost 2.4: East Deering stockyard with resting pens for 2,500 head of export livestock and 15-stall roundhouse with steam locomotive servicing facilities (station closed 1939)