Survival motor neuron spinal muscular atrophy

Survival Motor Neuron Spinal Muscular Atrophy


Survival motor neuron spinal muscular atrophy

to get instant updates about 'Survival Motor Neuron Spinal Muscular Atrophy' on your MyPage. Meet other similar minded people. Its Free!


All Updates

Survival motor neuron spinal muscular atrophy (Spinal muscular atrophies of childhood) is a term used used to describe certain forms of spinal muscular atrophy (SMA) that are associated with the Survival of Motor Neuron (SMN) protein. These include Werdnig-Hoffmann disease and Kugelberg-Welander disease.

It can involve SMN1 and SMN2.

Sometimes the term "spinal muscular atrophy" is used to imply an association with survival motor neuron, but the phrase "spinal muscular atrophy" is also used to refer to unrelated conditions such as Kennedy disease.

The term dates back to at least 1973.


The most common form of SMA is caused by mutation of the SMN gene, and manifests over a wide range of severity affecting infants through adults. This spectrum has been divided into groups, depending on the age of onset, and are as followed:


It has been linked to an abnormal survival motor neuron (SMN) gene.

In humans and chimps, the region of chromosome 5 that contains the SMN (survival motor neuron) gene has a large duplication. A large sequence that contains several genes occurs twice—i.e. once in each of the adjacent segments. A second change that is found only in humans is that the two copies of the gene—known as SMN1 and SMN2—differ by only a few base pairs. The important change in the SMN2 gene, for the purposes of SMA, is a silent mutation that occurs at...
Read More

No feeds found

Posting your question. Please wait!...


No messages found
Suggested Pages
Tell your friends >
about this page
 Create a new Page
for companies, colleges, celebrities or anything you like.Get updates on MyPage.
Create a new Page
 Find your friends
  Find friends on MyPage from