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T-cadherin also known as cadherin 13, H-cadherin (heart) (CDH13) is a unique member of cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. Classical cadherins are necessary for cell–cell contacts, dynamic regulation of morphogenetic processes in embryos and tissue integrity in adult organism. Cadherins function as membrane receptors mediating outside-in signals, activating small GTPases and beta-catenin/Wnt pathway, and resulting in dynamic cytoskeleton reorganization and changes in the phenotype.

T-cadherin is a GPI-anchored member of cadherin superfamily, which lacks a direct contact with cytoskeleton and therefore is not involved in cell–cell adhesion. It is involved in low density lipoproteins (LDL) hormone-like effects on Ca<sup>2+</sup>-mobilization and increased cell migration as well as phenotype changes. Exact signaling partners and adapter proteins for T-cadherin remain to be elucidated.

Mediation of intracellular signaling in vascular cells

Though T-cadherin can mediate weak homophilic adhesion in aggregation assays in vitro, the lack of intracellular domain suggests that Т-cadherin is not involved in stable сеll-сеll adhesion. In vivo T-cadherin was detected оn the apical сеll surface of the chick interstinal epithelium. In cultures of transfected MDCS cells, T-cadherin was also expressed apically, whereas N-cadherin located basolaterally...
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