Her father was the Colombian businessman Julio Mario Santo Domingo, Jr. Her mother, Vera Rechulski is a socielite of São Paulo, but lives in Rio de Janeiro. Her brother is Julio Mario Santo Domingo III. Her uncle Alejandro Santo Domingo was listed on Vanity Fair's 67th annual International Best Dressed List, September 2006, alongside his then-girlfriend, Spanish fashion model Eugenia Silva. Another uncle, Andres Santo Domingo, is married to the US Vogue contributing editor Lauren Davis.