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Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.


TCF3 has been shown to interact with ID3, LYL1, Twist transcription factor, PCAF, LMX1A, LDB1, ELK3, CBFA2T3, MyoD, EP300, CREB-binding protein, MAPKAPK3, Myogenin, TAL1 and UBE2I.<ref......
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