Thriller was created by Hubbell Robinson for Revue Studios (later purchased by Universal Studios). It was produced by Fletcher Markle, William Frye, and Maxwell Shane. Among the many writers for the series was Robert Bloch, who adapted a number of his own stories, notably The Weird Tailor.
In addition to serving as the host of the series, Karloff starred in five episodes: "The Prediction," "The Premature Burial," "The Last of the Somerviles," "Dialogues With Death," and "The Incredible Doktor Markesan." Other players included William Shatner (in two episodes), Scott Marlowe, and Judson Pratt. Child actressBeverly Washburn appeared as Lolly Howard in the 1961 episode "Parasite Mansion". Dayton Lummis appeared as Clarence in "The Cheaters" (1960) and as Millard Braystone in "Cousin Tundifer" (1962). Joan Tompkins appeared twice on Thriller too as Ellen Grimm in "The Cheaters" (1960) and Laura Craig in "Mr. George" (1961). Elizabeth Montgomery, Tom Poston, and John Carradine starred in the episode "Masquerade".