Trans-activation response element (TAR)

Trans-Activation Response Element (TAR)

Trans-activation response element (TAR)

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The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin acts as a binding site for the Tat protein and this interaction stimulates the activity of the long terminal repeat promoter.

Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from under-going apoptosis by down-regulating the genes ERCC1 and IER3.


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