Uncle Anesthesia is the Screaming Trees' fifth album and first full-length album release on Epic Records, released on January 29, 1991. It includes two of the four tracks from the band's previous Epic release, 1990's Something About Today EP, including the song that would give the LP its title. The album, recorded throughout June 1990, was the last to feature drumming by original member Mark Pickerel, who left on amicable terms in 1991 to work in a variety of projects. He would be replaced by Barrett Martin.
Uncle Anesthesia was co-produced by noted heavy metal specialist Terry Date and Soundgarden vocalist Chris Cornell. Despite the major label backing, the album failed to expand the Trees' audience beyond its existing fanbase. However, "Bed of Roses" was released as a single and became a minor hit on the Modern Rock charts.