The band featured members James Spadaccini, John Farnsworth, Lindsey Anderson, Chip Moody, Chuck "Wheat" Weaver, and Richard Hall (who later went on to success under the name "Moby"). The band was formed in 1982 and released its first 7" EP entitled, Hit Squad for God in 1983. Richard Hall (Moby) is credited as "M.H." on the back cover of the release. Later members included Dave Hower, Mike Pollock, and Matt Craig. The band went on to release the Just a Frisbee 7" EP later in 1983 and Point Me to the End 12" EP in 1984. The "Just a Frisbee" 7"cover artwork was drawn by Rob Zombie, founder and lead singer of White Zombie. The Vatican Commandos disbanded in 1985.
After 25 years, the band has reformed and played a reunion show July 17 at the Mercury Lounge in New York City. A west coast reunion show is planned for February 5, 2011 at The Dragonfly in Hollywood, CA.