State Route 42 (VA-42) is a primary state highway in the U.S. state of Virginia. Running parallel to and west of Interstate 81, SR 42 consists of three sections with gaps filled by secondary routes in between. According to VDOT traffic counts, SR 42 is connected along these routes (mainly State Route 730 and State Route 615), but these roadways are not signed as or otherwise considered to be SR 42.