is a sulfonamide diuretic
drug marketed by Eli Lilly
under the trade names Aquaphor
(in Germany) and Aquaphoril
(in Austria). It is used for the treatment of oedema
Mechanism of action
Like the structurally related thiazide diuretics
, xipamide acts on the kidneys to reduce sodium
reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. This leads to increased urinary output. Unlike the thiazides, xipamide reaches its target from the peritubular side (blood side).
Additionally, it increases the secretion of potassium
in the distal tubule and collecting ducts. In high doses it also inhibits the enzyme carbonic anhydrase
which leads to increased secretion of bicarbonate and alkalizes the urine.
Unlike with thiazides, only terminal renal failure
renders xipamide ineffective.
Xipamide is used for
After oral administration, 20 mg of xipamide are resorbed quickly and reach the peak plasma concentration of 3 mg/l... Read More