RNA polymerase II

RNA Polymerase II

RNA polymerase II

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RNA polymerase II (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase. A wide range of transcription factors are required for it to bind to its promoter and begin transcription.


The eukaryotic core RNA polymerase II was first purified using transcription assays.

Computer generated image of POLR2A gene colorized subunits: <span style="color: #00ff00;">green</span> - RPB1 domain 1, <span style="color: #0000ff;">blue</span> - RPB1 domain 2, <span style="color: #C2B280;">sand</span> - RPB1 domain 3, <span style="color: #87CEEB;">light blue</span> - RPB1 domain 4, <span style="color: #964B00;">brown</span> - RPB1 domain 6, and <span style="color: #ff00ff;">magenta</span> - RPB1 CTD.

  • DNA-directed RNA polymerase II subunit RPB1 - an enzyme that in humans is encoded by the POLR2A gene. RPB1 is the largest......
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